The human embryonic lethal abnormal vision-like protein, HuR, is a member of the Hu family of RNA-binding proteins. Over the past decade, this ubiquitously expressed protein has been extensively investigated in cancer research because it is involved in the regulation of mRNA stability and translation in many cell types.
2018-12-08 · Human antigen R (HuR) functions as a major post-transcriptional regulator of gene expression through its RNA-binding activity. HuR is composed by three RNA recognition motifs, namely RRM1, RRM2, and RRM3. The two N-terminal RRM domains are disposed in tandem and contribute mostly to HuR interaction with adenine and uracil-rich elements (ARE) in mRNA. Here, we used a combination of NMR and
MEF2C is upregulated by binding of RNA stabilizing protein, HuR (alias ELAVL1). The association of HuR protein and MEF2C mRNA protects MEF2C mRNA from degradation. Human antigen R (HuR) is a member of the Hu family of RNA-binding proteins. This molecule, which was first described in tumors nearly two decades ago, has recently received much attention in tumor-related research because it regulates the expression of many tumor-associated molecules through posttranscriptional regulatory mechanisms, thereby affecting biological characteristics. The RNA-binding protein HuR post-transcriptionally regulates mRNA splicing. Turner and colleagues demonstrate that HuR serves a critical role in thymus-independent antigen responses by regulating Protein 1, ELAVL1) is an RNA-binding protein,26 it may effect the stabilization of mRNAs so as to regulate their expression and is in-volved in various biological progresses.
We show that activation of the RNA-binding protein Hu antigen R (HuR) is increased in glomerulosclerosis not only in anti-Thy 1.1 nephritis model but also in varied human glomerular diseases. 2021-04-04 · RNA-binding protein HuR regulates translation of vitamin D receptor modulating rapid epithelial restitution after wounding. Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis. Human antigen R protein modulates vascular endothelial growth factor expression in human corneal epithelial cells under hypoxia. 2011-12-27 · Several studies have linked the RNA-binding protein HuR, which increases mRNA stability, with malignant transformation.
HuR CD4+ T cells from over-expressing transgenic mice. RNA-binding proteins coordinate the fates of multiple RNAs, but the principles binding protein HuR, by integrating data from diverse high-throughput targeting May 31, 2018 RNA binding protein HuR promotes osteosarcoma cell progression via suppressing the miR‑142‑3p/HMGA1 axis.
PDCD4 mRNA translation is regulated by an interplay between the oncogenic microRNA miR-21 and the RNA-binding protein (RBP) HuR in response to LPS stimulation, but the role of other regulatory factors remain unknown.
Gene ID (Entrez), 100526737. Name, RNA-binding protein 14 Protein.
RATIONALE: The RNA binding protein (RBP), HuR, (elavl1) has been shown to mRNA targets. HuR CD4+ T cells from over-expressing transgenic mice.
Type: Primary Antigen: Musashi-1 RNA Binding Protein Clonality: monoclonal av N Henriksson · 2009 — in complex with a plethora of RNA-binding proteins, building up messenger ribonucleoproteins Stabilizing factors such as HuR (Ford et al.,. RNA Genomics Solution company empowering RNA Researchers around the to profile binding sites for RNA binding proteins, using enhanced crosslinking Further, human Antigen-R (HuR, a RNA binding protein, which binds to the 3'-untranslated region of the β-AR mRNA and promotes RNA degradation, was en fosfatgrupp. I DNA är sockret deoxyribos och i RNA ribos: ”Single strand binding proteins”: Binder till enkelsträngat DNA Antalet koder är korrelerat till hur. TATA-bindande protein (TBP) är en transkriptionsfaktor som binder specifikt till en typ en generell transkriptionsfaktor som i sin tur utgör en del av RNA-polymeras baserad på material från engelskspråkiga Wikipedia, TATA binding protein, RNA Binding Proteins: New Concepts in Gene Regulation: 16: Sandberg, Kathryn, Mulroney,: Amazon.se: Books. Branchpoint binding protein binder in till Branchpoint samt U2AF hjälpprotein -Stänger transkription oavsett hur många aktivatorer det finns. RNA pol 1. The RNA-binding protein, HuR, associates with the HuR mRNA, but the consequences of this interaction are unknown.
Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity).
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2019-12-03 · Herein, we show that the ablation of RNA-binding protein HuR in NSCs impairs adult but not embryonic neurogenesis. HuR is predominantly expressed in the cytoplasm of embryonic NSCs but translocates into the nucleus of adult NSCs. ubiquitously expressed mRNA-binding protein (mRBP) HuR(ELAVL1)isapostulatedstress-relevantproteinthat binds to adenylate uridylate (AU)–rich sites within regu-latory mRNA targets and regulates their expression via post-transcriptional mechanisms (12). These binding sites typically reside within 39–UTRs of target transcripts. HuR, a protein that binds to specific mRNA subsets, is increasingly recognized as a pivotal posttranscriptional regulator of gene expression.
RNA pol 1.
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Growing evidence shows that cancer cells use mRNA-binding proteins and miRNAs to posttranscriptionally regulate signaling pathways to adapt to harsh tumor microenvironments. In ovarian cancer, cytoplasmic accumulation of mRNA-binding protein HuR (ELAVL1) is associated with poor prognosis. In this study, we observed high HuR expression in ovarian cancer cells compared with ovarian primary cells
This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements.